British Air Force Typhoon FGR4s have joined forces with French warplanes in a coordinated attack on an hidden munitions depot in Syrian territory used by the Islamic State group (IS), according to the British defence ministry.
The facility, located using intelligence, was thought to be storing arms and explosives, the release indicated, and was located in mountains just to the north of the ancient city of Palmyra in Syria's central region.
"Our aircraft used Paveway IV guided bombs to target a number of access tunnels providing entry to the site... early reports indicate the strike was effective," the MoD said.
There was no indication of any civilian casualties in the attack conducted Saturday night and all the aircraft made a safe return, the defence officials confirmed.
The British jets were supported by a Voyager refuelling tanker.
Daesh - referred to as Daesh - enforced jihadist rule over parts of both Syria and Iraq until 2019.
"This strike underscores the UK's leading role, and determination to operate in unison with our partners, to eliminate any revival of Daesh and their harmful and extremist ideologies in the region," the British Defence Secretary the minister said.
RAF aircraft have carried out surveillance missions over Syrian airspace to "forestall any efforts to regroup" of Islamic State subsequent to its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I extend gratitude to all the members of our armed forces who took part in this operation for their professionalism and their bravery," he added. "They were among a great many British personnel on duty over Christmas and New Year. This mission, to remove militants who threaten our safety, highlights how British military are ready to step up, continuously, keeping Britain secure at home and powerful internationally."
In December, the US military carried out what it termed a "major assault" targeting Islamic State objectives in the country, after an attack killed two US servicemembers and a civilian interpreter in Palmyra.
The UN says Islamic State still maintains roughly 5-7 thousand combatants in Syria and Iraq.